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Homogeneously staining regions and tumorigenicity
Author(s) -
Gilbert Fred,
Balaban Gloria,
Brangman Deborah,
Herrmann Nira,
Lister Ann
Publication year - 1983
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910310615
Subject(s) - retinoblastoma , staining , chromosome , biology , cell culture , microbiology and biotechnology , gene duplication , abnormality , gene , chromosome abnormality , pathology , genetics , karyotype , medicine , psychiatry
A homogeneously staining region (HSR), a chromosome abnormality associated with gene amplification, was found to increase in length coincident with an enhancement in tumorigenicity when cells from a human retinoblastoma cell line were serially passaged in athymic (nu/nu) mice.
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