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Site‐directed chemotherapy with a drug bound to anti‐idiotypic antibody to a lymphoma cell‐surface IgM
Author(s) -
Hurwitz Esther,
Kashi Rina,
Burowsky Daphna,
Ar Ruth,
Haimovich Joseph
Publication year - 1983
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910310612
Subject(s) - lymphoma , drug , antibody , chemotherapy , surface immunoglobulin , medicine , cancer research , immunology , b cell , pharmacology
Xenogeneic antibodies against the cell‐surface IgM of a B‐cell lymphoma (38C‐13) were coupled through a dextran bridge to the anti‐neoplastic drug, daunomycin. The conjugate maintained both its antibody and its drug activity. The effectiveness of the conjugate was tested in vivo in mice challenged with the 38C‐13 lymphoma. Drug conjugates of the idiotypic antibodies injected intraperitoneally 2 days after tumor transplantation almost completely inhibited tumor development. The controls, daunomycin‐dextran‐goat anti‐DNP, free daunomycin, or the antibodies alone had no effect or only delayed the tumor development.