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Antitumor effects of interferon in mice injected with interferon‐sensitive and interferon‐resistant friend leukemia cells. III. Inhibition of growth and necrosis of tumors implanted subcutaneously
Author(s) -
Belardelli F.,
Gresser I.,
Maury C.,
Duvillard P.,
Prade M.,
Maunoury M.T.
Publication year - 1983
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910310518
Subject(s) - interferon , spleen , necrosis , leukemia , neoplasm , ratón , interferon alfa , interferon gamma , tumor necrosis factor alpha , alpha interferon , cancer research , immunology , medicine , biology , pathology , cytokine
Administration of highly purified interferon to DA/2 mice inhibited the growth of interferon‐sensitive or interferon‐resistant Friend erythroleukemia cells implanted subcutaneously. Injection of interferon at the site of tumor inoculation was more effective than injection of interferon intraperitoneally. Histologic examination of tumors in interferon‐treated mice showed extensive areas of tumor‐cell necrosis in the absence of an obvious host‐cell infiltrate. Interferon inhibited the growth of established subcutaneous tumors and induced complete tumor regression in some mice. Interferon treatment also resulted in an inhibition of tumor metastases in the liver and spleen.