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Melanoma‐associated antigen p97 continues to be expressed after prolonged exposure of cells to specific antibody
Author(s) -
Hellström Ingegerd,
Brown Joseph P.,
Hellström Karl Erik
Publication year - 1983
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910310505
Subject(s) - monoclonal antibody , epitope , melanoma , antibody , antigen , immunology , glycoprotein , monoclonal , medicine , cancer research , biology , virology , microbiology and biotechnology
p97, a 97,000 molecular weight cell surface glycoprotein associated with human melanoma, has attracted attention as a possible target for tumor therapy. Melanoma cells were grown overnight in the presence of IgG2a or IgGI monoclonal antibodies specific for p97, and then exposed to complement and also tested for binding of monoclonal antibodies specific for other epitopes of p97. The results indicated that melanoma cells continued to express p97 after prolonged exposure to specific antibody, a prerequisite for many therapeutic applications.