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A study of glial fibrillary acidic protein (GFAP) in childhood brain tumours
Author(s) -
Marsden H. B.,
Kumar S.,
Kahn J.,
Anderton B. J.
Publication year - 1983
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910310408
Subject(s) - glial fibrillary acidic protein , astrocytoma , medulloblastoma , pathology , glioma , medicine , anaplastic astrocytoma , immunohistochemistry , biology , cancer research
A retrospective study of 366 primary brain tumours in childhood has been carried out. GFAP was detected in juvenile astrocytoma (76/121), adult astrocytoma (34/78), malignant glioma (0/8), other astrocytic tumours (2/4) and medulloblastoma (0/101). In eight medulloblastomas scanty positive cells were seen but were regarded as reactive rather than neoplastic. The presence of GFAP was only found to be of prognostic value in adult astrocytoma, where its occurrence was associated with a more favourable outcome.