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Genetic control of the organ specificity of lymphoproliferative disease virus (LPDV) of Turkeys
Author(s) -
Gazit Ara,
Yantv Abraham,
Ilani Aviva,
Ianconescu Marius,
Perk Kalman,
Zimber Amatzia
Publication year - 1983
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910310316
Subject(s) - virus , biology , virology , viral replication , lymphatic system , lymphoproliferative disease , gene , lymphoproliferative disorders , immunology , lymphoma , genetics
In a previous study based on the kinetics of virus replication and tumor formation (Gazit et al. , 1982), it was shown that the organotropism of lymphoproliferative disease virus (LPDV) is confined to lymphoid tissues. The present paper demonstrates that this organ specificity is controlled at the level of infection and integration, that is, the lymphoid organs, which are the only organs sustaining virus replication, and also the only organs in whose cells integrated LPDV proviruses are detectable. At the same time, the efficiency of virus replication within the various target organs is regulated both at the level of infection and integration and at the level of viral gene transcription.