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Evidence for involvement of the immunoglobulin heavy‐chain gene locus in the 8:14 translocation of human B lymphomas
Author(s) -
McIntosh R. V.,
Cohen B. B.,
Steel C. M.,
Read Helene,
Moxley Marion,
Evans H. J.
Publication year - 1983
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910310304
Subject(s) - chromosomal translocation , immunoglobulin heavy chain , biology , antibody , immunoglobulin light chain , gene , locus (genetics) , b cell , chromosome , heavy chain , genetics , microbiology and biotechnology , immunology
Abnormalities of immunoglobulin (Ig) heavy chain synthesis occurring in human B lymphoid cell lines of malignant origin suggest that the Ig heavy‐chain gene complex is involved in the 8:14 chromosome translocation which these cells carry.