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Epstein‐barr virus (EBV)‐induced lymphoproliferative disease in cotton‐topped marmosets
Author(s) -
Johnson Donald R.,
Wolfe Lauren G.,
Levan Göran,
Klein George,
Ernberg Ingemar,
Åaman Pierre
Publication year - 1983
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910310115
Subject(s) - lymphoproliferative disorders , mononucleosis , virus , virology , lymphoma , biology , epstein–barr virus , antibody , polyclonal antibodies , marmoset , immunology , lymphoproliferative disease , surface immunoglobulin , b cell , paleontology
Six cotton‐topped marmoset monkeys ( Sangiunus oedipus ) were inoculated with 10 5 tranforming units of B95‐8 virus, and two of them developed fatal lymphoproliferative disease. The EBV‐carrying tumor cells from these marmosets had the following characteristics: (I) they were polyclonal by surface immunoglobulin and immunoglobulin production in vitro; (2) they had no specific chromosome abnormalities, and (3) they failed to form colonies in large percentages in agarose. It is proposed that a spectrum of phenotypes of EBV‐induced lympho‐proliferative diseases in the cotton‐topped marmosets may be identified and are more akin to fatal infectious mononucleosis or X‐linked lymphoproliferative syndrome than to Burkitt's lymphoma.