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Modulation of natural killer (NK) cell activity during FLV‐P virus infection of mice
Author(s) -
Migliorati Graziella,
Jezzi Teresa,
Frati Luigi,
Bonmassar Enzo,
Rossi Giovanni B.,
Garaci Enrico,
Riccardi Carlo
Publication year - 1983
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910310114
Subject(s) - virus , splenocyte , natural killer cell , population , in vitro , immunology , lytic cycle , biology , friend virus , macrophage , microbiology and biotechnology , spleen , endocrinology , cytotoxicity , medicine , biochemistry , environmental health
We analyzed the effects of a polycythemic substrain of Friend leukemia virus, i.e. the FLV‐P virus, on splenic NK activity of DBA/2 susceptible mice. One day after virus injection a significant increase of NK activity was found, which persisted until day 10. On the other hand, 14‐21 days after virus injection a marked and significant depression of activity was measured. This depression was associated with the appearance of suppressor cells able to inhibit the lytic activity of untreated splenocytes when mixed in vitro in the 4 h 51 Cr‐release assay. The suppressor cell population was insensitive to treatment with anti‐Thy 1.2 plus complement, was adherent to Sephadex G‐10 and nylon, but did not adhere to plastic, suggesting it is neither a T‐cell nor a typical macrophage. The possible relevance of NK activity modulation in relation to the induction of leukemia is discussed.