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Splenic variations affecting sarcomagenesis among mice of an inbred strain
Author(s) -
Prehn Richmond T.,
Karcher Christine A.
Publication year - 1983
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910310111
Subject(s) - strain (injury) , inbred strain , biology , mouse strain , immunology , pathology , medicine , genetics , anatomy , gene
Among overtly identical mice of an inbred strain, some are relatively susceptible and some relatively resistant to sarcomagenesis by large concentrations of 3‐methyl‐cholanthrene (MCA) (Prehn, 1975a). Spleen cells from mice, subsequently shown to be relatively susceptible, conveyed a relative resistance to oncogenesis when transferred to irradiated recipients; spleen cells from mice, subsequently shown to be relatively resistant, conveyed to secondary hosts a relative susceptibility.