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Elevation of serum placental alkaline phosphatase levels in cigarette smokers
Author(s) -
Tonik Susan E.,
Ortmeyer Ann E.,
Shindelman Jeffrey E.,
Sussman Howard H.
Publication year - 1983
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910310109
Subject(s) - medicine , alkaline phosphatase , placental alkaline phosphatase , endocrinology , cigarette smoking , gastroenterology , physiology , biology , enzyme , biochemistry
In an ongoing longitudinal study for tumor markers in breast cancer patients, levels of placental alkaline phos‐phatase (PAP) measured by RIA were found to be elevated in 34% of patients who smoked cigarettes as opposed to 5 % of non‐smoking subjects. A normal range was established (0‐2.14 ng/ml) using healthy non‐smoking females. In an expanded analysis by disease state, PAP levels were found to be elevated significantly (p<0.02) in the smoking groups of each category. This isoenzyme, when detected at elevated serum levels by RIA, was enzymatically active in 48% of the patients as analyzed by immunoenzymatic assay. One smoker with high PAP levels discontinued smoking following a myocardial infarction. Her PAP levels returned to normal within 2 months.