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Paradoxical anti‐leukemic effects of plant‐derived tumor promoters on a human thymic lymphoblast cell line
Author(s) -
Nakao Yoshinobu,
Matsuda Shuichi,
Kimoto Hiroyuki,
Matsui Toshimitsu,
Kobayashi Nobuhisa,
Kishihara Michizo,
Fujita Takuo,
Watanabe Shaw,
Ueda Kunihiro,
Ito Yohei
Publication year - 1982
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910300603
Subject(s) - cell culture , biology , lymphoblast , phenotype , cellular differentiation , receptor , phorbol , cell , leukemia , sodium butyrate , biochemistry , protein data bank (rcsb pdb) , microbiology and biotechnology , protein kinase c , immunology , signal transduction , genetics , gene
Three different diterpen polyols and the teleocidin have antileukemic effects on the human thymic leukemia cell line HPB‐ALL by inducing phenotypic differentiation. We tested TPA (phorbol esters), mezerein (daphnane), milliamin (ingenol ester) and teleocidin B (teleocidins) as representative of the chemical structure of each principle and found that these agents have the similar biological activity of inducing phenotypic differentiation in HPB‐ALL cells. Moreover, competitive binding of [ 3 H]PDB to cell‐surface receptors was significantly inhibited by these agents; n ‐butyrate and phorbol per se did not inhibit the binding of [ 3 H]PDB. Despite differences in the structure of the principles, these agents may have similarly acting side‐chain structures.