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Epstein‐Barr virus induction by a serum factor: IV. Ubiquitous occurrence of the factor within vertebrates and its interaction with defined lymphoid cell lines
Author(s) -
Wittmann Peter,
Höfler Petra,
Bauer Georg
Publication year - 1982
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910300418
Subject(s) - epstein–barr virus , virus , lymphoma , raji cell , biology , lymphoblast , cell culture , antigen , immunology , virology , genetics
We have recently reported the existence of a serum factor that induces Epstein‐Barr virus antigens in Raji cells (Bauer et al. , 1982 b, c ). Here we demonstrate the ubiquitous presence of this factor in sera of vertebrates of all five classes. Furthermore, we tested 48 EBV‐genomepositive lymphoid cell lines of different origins for responsiveness to the serum factor. Only cells from lines of two groups, i.e. Burkitt's lymphoma and EBV‐transformed marmoset lines, responded to the factor, whereas human lymphoblastoid cell lines were not induced by the serum factor.