Premium
Papillary carcinomas of the thyroid have pore‐deficient nuclei
Author(s) -
Johannessen Jan Vincents,
SobrinhoSimöes Manuel,
Finseth Inga,
Pilström Lars
Publication year - 1982
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910300405
Subject(s) - pathology , nuclear pore , thyroid , lymph node , cytoplasm , papillary carcinoma , thyroid carcinoma , follicular phase , medicine , chemistry , cancer research , biology , endocrinology , microbiology and biotechnology
A significant reduction in nuclear pore density observed in papillary carcinomas compared to normal thyroid, adenomas and follicular carcinomas probably disturbs the nucleo‐cytoplasmic transfer of ribonucleoproteins. This may contribute to the slow growth and indolent biological behavior of these tumors where even the presence of regional lymph node metastases does not worsen the prognosis. The signs of nuclear hyperactivity may result from an attempt to compensate for the nuclear membrane defect.