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High‐ and low‐leukemogenic variants of the radiation leukemia virus (RadLV) differ in ability to induce tumor‐specific immune suppression
Author(s) -
Yefenof Eitan,
Zilcha David
Publication year - 1982
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910300316
Subject(s) - biology , suppressor , immune system , cytotoxic t cell , virus , virology , leukemia , cancer research , immunology , in vitro , genetics , cancer
Adult C57BL/6 mice inoculated intrathymically (i.t.) with the highly leukemogenic variant of the radiation leukemia virus (A‐RadLV) develop suppressor cells capable of specifically abrogating a potential anti‐tumor cytotoxic response in vitro . Suppressor cells were generated directly by the virus, independently of an initiation of a leukemogenic process. Inoculation of C57BL/6 animals with the low leukemogenic D‐RadLV variant did not result in suppressor cell generation. It is proposed that induction of tumor‐specific immune suppression by A‐RadLV is essential for tumor progression, and the leukemogenic activity of D‐RadLV is attributed to its inability to recruit suppressor cells.