Premium
Interferon and natural killer activity in multiple myeloma. Lack of correlation between interferon‐induced enhancement of natural killer activity and clinical response to human interferon‐α
Author(s) -
Einhorn Stefan,
Ahre Anders,
Blomgren Henric,
Johansson Bo,
Mellstedt Håkan,
Strander Hans
Publication year - 1982
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910300207
Subject(s) - interferon , in vivo , natural killer cell , multiple myeloma , immunology , in vitro , interferon type i , alpha interferon , medicine , biology , cytotoxicity , biochemistry , microbiology and biotechnology
Natural killer (NK) activity of peripheral lymphocytes was measured in 39 patients with multiple myeloma prior to and during interferon (IFN) therapy. NK activity increased in a majority of patients following the first injection of IFN and remained at an increased level during I year of therapy. Lower doses of IFN seemed to induce a greater increase in NK activity than higher doses. No correlations could be observed between the response of the tumors to IFN therapy and pretreatment levels of NK activity, IFN‐induced enhancement of NK activity in vitro or IFN‐induced enhancement of NK activity in vivo .