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Growth responses of rat stomach cancer cells to gastro‐entero‐pancreatic hormones
Author(s) -
Kobori Oichiro,
Vuillot MarieThérèSe,
Martin François
Publication year - 1982
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910300112
Subject(s) - gastro , stomach , hormone , pancreatic cancer , cancer , growth hormone , medicine , endocrinology , pancreas , biology , disease , reflux
Various hormones and peptides were added to rat stomach cancer cells growing in vitro in a serum‐free medium and the cell number was determined by a spectro‐photometric method. Five gastro‐entero‐pancreatic hormones or related peptides (tetragastrin, glucagon, secretin, cholecystokinin‐pancreozymin and cerulein) significantly increased the number of stomach cancer cells from 150% to 310% of the number of control cells cultivated in a serum‐free, hormone‐free medium. On the other hand, insulin and vasoactive intestinal peptide, and other hormones (thyroxin, epinephrine, hydrocortisone, β‐estradiol, progesterone, testosterone), peptone broth and bovine serum albumin had no significant growth effect. All the active substances belong to the two major families of gastro‐entero‐pancreatic polypeptide hormones, suggesting the existence of hormone receptors at the surface of stomach cancer cells.