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Anti‐tumor immunity in b‐lymphocyte‐deprived mice. iii. immunity to primary moloney sarcoma virus‐induced tumors
Author(s) -
Gordon Julius,
Holden Howard T.,
Segal Shraga,
Feldman Michael
Publication year - 1982
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910290320
Subject(s) - sarcoma , immunity , metastasis , virus , antibody , spleen , immune system , neoplasm , cellular immunity , immunology , primary tumor , medicine , lymphocyte , biology , pathology , cancer research , cancer
Abstract Tumor induction and immunity to tumors were studied following the injection of Moloney sarcoma virus (MSV) into mice whose B‐lymphocyte functions had been suppressed by the chronic administration of anti‐IgM antibodies. Two preparations of MSV were used; one which gives rise to tumors which uniformly regress in normal adult mice, and another which elicits progressively growing tumors in the majority of recipients. The tumor incidence, mean tumor size, and tempo of regression were not modified by treatment with anti‐IgM. However, whereas tumors induced by the regressor virus were all rejected in 19 NRG‐treated and 29 untreated recipients, continued growth was obtained in 2 of 23 B‐lymphocytedeprived mice. Furthermore, in 9 additional mice from this group, apparent rejection was followed by tumor recurrence at the site of the initial tumor. Continued growth was accompanied by widespread metastasis. These tumors were freely transplantable to normal syngeneic recipients. Metastasis and transplantability were also detected in 7 of 24 anti‐IgM‐treated mice given progressor virus, but were not seen in the control animals. Recurrence and metastasis was obtained despite the presence of high levels of specific cytotoxic T lymphocytes in the spleen. It is concluded that B lymphocytes or their products play an essential role in host protection against MSV‐induced tumors.