Premium
Characterization of a highly oncogenic murine leukemia virus from wild mice
Author(s) -
Rasheed Suraiya,
Pal Bijay K.,
Gardner Murray B.
Publication year - 1982
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910290319
Subject(s) - virus , virology , murine leukemia virus , biology , recombinant dna , recombinant virus , cell culture , gene , genetics
We have isolated a highly lymphomagenic wild mouse virus by passage of a weakly oncogenic amphotropic murine leukaemia virus (MuLV‐A) in NIH Swiss mice. This virus is similar in host range, interference and neutralization properties to that of the inoculated amphotropic virus but is distinct from it biochemically and causes lymphomas in 90‐100% of mice within 1‐2 months. Our results indicate that this highly oncogenic virus is a recombinant of wild mouse MuLV‐A and sequences related to env gene region of the endogenous xenotropic virus of NIH Swiss mice.