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A cell‐surface antigen which is present in the ganglioside fraction and shared by human melanomas
Author(s) -
Yeh M.Y.,
Hellström I.,
Abe K.,
Hakomori S.,
Hellström K. E.
Publication year - 1982
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910290308
Subject(s) - antigen , melanoma , ganglioside , human lung , antibody , cell , biology , biopsy , pathology , microbiology and biotechnology , immunology , chemistry , cell culture , cancer research , medicine , biochemistry , genetics
We have raised a hybridoma, 4.2, which forms an IgM antibody to an antigen expressed on cultivated cells from most human melanomas, more infrequently on cells from other human tumors, and very weakly on cultivated fibroblasts, T cells and B cells. The antigen can be detected in biopsy material of human melanoma and, in smaller amounts, in fresh samples of normal human lung and kidney. Preliminary biochemical characterization indicates that it is associated with the ganglioside fraction. We feel that the antigen (referred to as 4.2) has a sufficient degree of tumor specificity to be rated as a human melanoma‐associated antigen.