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Complement‐fixing antibody to epstein‐barr virus soluble antigen in populations at high and low risk for nasopharyngeal carcinoma
Author(s) -
Levine Paul H.,
Connelly Roger R.,
Mestre Miguel,
Ebbesen Peter,
Das Saroj,
Middleton Moses
Publication year - 1982
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910290307
Subject(s) - antigen , antibody , nasopharyngeal carcinoma , immunology , virus , epstein–barr virus , antibody titer , virology , biology , titer , incidence (geometry) , medicine , physics , optics , radiation therapy
Greenland Eskimos comprise an ethnic group with one of the highest recorded incidence rates for nasopharyngeal carcinoma in the world. Sera from 625 Eskimos and 73 Danes (Caucasians) living in Greenland, as well as from 62 Danes living in Denmark, were tested for complement‐fixing antibody to Epstein‐Barr virus (EBV) soluble antigen and, from this study group, 129 donors were matched by age and sex for a study comparing antibody to viral capsid antigen, early antigen, and soluble antigen. Both Eskimos and Danes living in Greenland had significantly higher titers of EBV antibodies than Danes living in Denmark, suggesting that environment was more important than genetics or socio‐economic factors in determining the antibody response to EBV. Age and sex were also factors, higher titers occurring in females and young Eskimos.