Detection of Epstein‐Barr viral DNA internal repeats in the nasopharyngeal mucosa of chinese with IgA/ebv‐specific antibodies | Zendy

Desgranges C. | Zendy; Bornkamm G. W. | Zendy; Zeng Y. | Zendy; Wang P. C. | Zendy; Zhu J. S. | Zendy; Shang M. | Zendy; DeThé G. | Zendy

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Detection of Epstein‐Barr viral DNA internal repeats in the nasopharyngeal mucosa of chinese with IgA/ebv‐specific antibodies

Author(s) -

Desgranges C.,

Bornkamm G. W.,

Zeng Y.,

Wang P. C.,

Zhu J. S.,

Shang M.,

DeThé G.

Publication year - 1982

Publication title -

international journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.475

H-Index - 234

eISSN - 1097-0215

pISSN - 0020-7136

DOI - 10.1002/ijc.2910290115

Subject(s) - nasopharyngeal carcinoma , antibody , epstein–barr virus , pathology , virus , immunoglobulin a , gammaherpesvirinae , biology , herpesviridae , immunology , medicine , virology , viral disease , immunoglobulin g , radiation therapy

Fifty‐six South Chinese individuals exhibiting IgA antibodies to EBV for 18 months and presenting naso‐pharyngeal abnormalities were biopsied. Four nasopha‐ryngeal carcinomas, two at a very early stage, were detected. In 14 further individuals, without clinical or his‐topathological evidence of tumor, EBV/DNA internal repeats and/or EBNA were detected in the biopsied mucosae. The presence of IgA/EBV antibodies and/or EBV markers in the nasopharyngeal mucosa may characterize pre‐cancerous conditions.

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