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Detection of Epstein‐Barr viral DNA internal repeats in the nasopharyngeal mucosa of chinese with IgA/ebv‐specific antibodies
Author(s) -
Desgranges C.,
Bornkamm G. W.,
Zeng Y.,
Wang P. C.,
Zhu J. S.,
Shang M.,
DeThé G.
Publication year - 1982
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910290115
Subject(s) - nasopharyngeal carcinoma , antibody , epstein–barr virus , pathology , virus , immunoglobulin a , gammaherpesvirinae , biology , herpesviridae , immunology , medicine , virology , viral disease , immunoglobulin g , radiation therapy
Fifty‐six South Chinese individuals exhibiting IgA antibodies to EBV for 18 months and presenting naso‐pharyngeal abnormalities were biopsied. Four nasopha‐ryngeal carcinomas, two at a very early stage, were detected. In 14 further individuals, without clinical or his‐topathological evidence of tumor, EBV/DNA internal repeats and/or EBNA were detected in the biopsied mucosae. The presence of IgA/EBV antibodies and/or EBV markers in the nasopharyngeal mucosa may characterize pre‐cancerous conditions.