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Synergistic effect of cis ‐dichlorodiammineplatinum and 5‐aza‐2′‐deoxycytidine on mouse leukemic cells in vivo and in vitro
Author(s) -
Veselý J.
Publication year - 1982
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910290114
Subject(s) - in vivo , deoxycytidine , in vitro , l1210 cells , leukemia , chemistry , cancer research , deoxycytidine kinase , dna synthesis , biology , microbiology and biotechnology , pharmacology , biochemistry , chemotherapy , immunology , genetics , cytotoxicity , gemcitabine
cis ‐Dichlorodiammineplatinum and 5‐aza‐2′‐deoxycytidine display a considerable synergistic effect in L1210 and La mouse leukemia in vivo ; the combination of both drugs is also clearly synergistic in vitro as evidenced by the effects on cell growth and cell survival in soft‐agar medium. In exponential but not in stationary growth of L1210 cells, the drugs interfere with DNA and RNA synthesis.