Premium
Luteinizing hormone‐releasing factor increases release of human chorionic gonadotrophin in isolated cell columns of normal and malignant trophoblasts
Author(s) -
Bützow R.
Publication year - 1982
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910290103
Subject(s) - syncytiotrophoblasts , endocrinology , choriocarcinoma , medicine , trophoblast , luteinizing hormone , stimulation , human chorionic gonadotropin , hormone , biology , chemistry , andrology , placenta , fetus , pregnancy , genetics
The effect of synthetic luteinizing hormone‐releasing factor (LRF) on release of human chorionic gonadotrophin (hCG) was studied by isolated cell columns of normal syncytiotrophoblasts and choriocarcinoma (BeWo) cells. After LRF stimulation the release of hCG by the normal trophoblasts increased up to 4‐fold and release by the malignant trophoblasts increased up to 6‐fold, indicating a specific effect of LRF on normal and malignant trophoblast cells.