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Relationship between fibrin clot retraction and tumorigenesis in C3H/10T1/2 cells
Author(s) -
Azzarone B.,
BroutyBoyé D.,
MacIeiraCoelho A.
Publication year - 1981
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910280619
Subject(s) - fibrin , carcinogenesis , cancer research , chemistry , biology , microbiology and biotechnology , immunology , cancer , genetics
Fibrin clot retraction (FCR) was studied in C3H/10T1/ 2 murine fibroblasts. These cells were able to induce FCR with high efficiency during resting phase as well as during active growth. C3H/10/T1/2 cells which became tumorigenic after X‐irradiation lacked FCR activity. Non‐tumorigenic revertant clones regained the capacity to induce FCR, while revertants which progressively back‐reverted to the neoplastic state showed intermediate FCR activity. These unstable revertants, when again fully tumorigenic, completely lost FCR activity.