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Intestinal M3 antigen, A marker for the intestinal‐type differentiation of gastric carcinomas
Author(s) -
Bara J.,
Hamelin L.,
Martin E.,
Burtin P.
Publication year - 1981
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910280609
Subject(s) - antigen , pathology , adenocarcinoma , biology , mucus , cancer , medicine , immunology , ecology
The mucus‐associated intestinal M3 antigen, normally restricted to intestinal goblet cells, was found in 35 out of 100 gastric adenocarcinomas belonging to intestinal (19/64) as well as diffuse (16/36) types according to Laurén's classification, often accompanying the other mucus‐associated gastric Ml and M2 antigens. This M3 antigen was predominant over the gastric M antigens in 25 of these 35 tumors; 18 of these belonged to the histological intestinal type. According to the WHO classification, the M3 antigen was found to predominate in all mucinous adenocarcinomas (7/7), was never present in the undifferentiated carcinomas (0/8), but was also found in some tubulo‐papillar (16/57) and signet‐ring cell (12/27) adenocarcinomas. This antigen could be used as a new criterion and incorporated into a point system containing morphological and tumor cell behavioral considerations; then it would appear to be a good marker for intestinal‐type differentiation. Indeed, 22 of these 25 gastric adenocarcinomas which produced predominantly M3 antigen showed such an intestinal‐like differentiation. The M antigenic pattern of gastric carcinoma suggested a duodenal rather than colonic‐type differentiation.