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Adjuvant reactivity predicts survival in patients with “high‐risk” primary malignant melanoma treated with systemic BCG
Author(s) -
Cochran Alistair J.,
Buyse Marc E.,
Lejeune Ferdy J.,
Macher Egon,
Revuz Jacques,
Rümke Philip
Publication year - 1981
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910280503
Subject(s) - medicine , melanoma , proportional hazards model , hazard ratio , breslow thickness , univariate analysis , oncology , univariate , survival analysis , confidence interval , multivariate analysis , surgery , cancer , multivariate statistics , statistics , sentinel lymph node , mathematics , cancer research , breast cancer
Abstract We report the prognostic importance of strength of reaction to BCG, tumor histology and clinical factors in patients with previously untreated high‐risk (Clark, III, IV and V) primary malignant melanoma. One hundred and one such patients received high‐dose BCG (1 × 10 8 viable units) by Heaf gun as an adjuvant to standardized primary surgery according to EORTC Protocol 18741. Univariate analysis of disease‐free interval (DFI) indicates that the degree of maximum reaction to BCG ( p = 0.0003), Breslow thickness ( p = 0.0003) and Clark level ( p = 0.002) are highly significant prognostic factors. When a multivariate model using Cox's proportional hazard regression was used for DFI, the degree of maximum reaction to BCG and Breslow thickness were by far the most significant criteria. A prognostic equation was obtained to predict DFI from maximum BCG reaction and Breslow thickness. From analysis of the “scores” calculated in this way it appears that the two variables act independently. This technique permits the determination of values that are predictive of DFI and discriminate between subgroups of patients with different DFI characteristics (5 groups, p < 0.0001). This exercise was repeated for survival and similar results were obtained. The degree of a patient's immune reaction to BCG administered therapeutically is of paramount importance in determining the likelihood of survival. This factor and the Breslow thickness can be integrated to produce a mathematical equation which accurately predicts survival for appropriately treated melanoma patients.