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Embryo‐derived teratocarcinoma. III. Development of tumors from teratocarcinoma‐permissive and non‐permissive strain embryos transplanted to F 1 hybrids
Author(s) -
Solter Davor,
Dominis Mara,
Damjanov Ivan
Publication year - 1981
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910280414
Subject(s) - teratocarcinoma , embryo , permissive , biology , hybrid , strain (injury) , ratón , embryonic stem cell , transplantation , phenotype , genetics , immunology , medicine , cellular differentiation , anatomy , gene , botany
Seven‐day‐old mouse embryos of two teratocarcinoma‐permissive (C3H and BALB/c) and two teratocarcinoma‐non‐permissive (C57BL/6 and AKR) strains were transplanted to their F 1 hybrids to determine the role of the genetic background of the recipient animals in controlling embryo‐derived teratocarcinogenesis. The yield of teratocarcinomas in F 1 hybrid recipients of embryonic grafts was either identical with the yield in syngeneic recipients or increased or decreased, depending on the strain of the embryo and the F 1 hybrid combination. In certain hybrids, the yield of malignant tumors remained the same as in the syngeneic recipients but the F 1 hybrids exerted a stimulatory effect on tumor growth and the tumors weighed more than those in syngeneic recipients. A matroclinous effect was also seen in certain hybrids. These data indicate that embryo‐derived teratocarcinogenesis in histocompatible F 1 mice depends on the genetic background of adult recipients. The teratocarcinogenic potential of non‐permissive and permissive strain mouse embryos can be modified by choosing appropriate F 1 hybrids for embryonic transplantations.