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Sister chromatid exchange in lymphoma lines and lymphoblastoid cell lines before and after heterotransplantation into nude mice
Author(s) -
Fonatsch Christa,
Kirchner Hartmut H.,
Schaadt Michael,
Günzel Manfred,
Diehl Volker
Publication year - 1981
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910280408
Subject(s) - sister chromatid exchange , cell culture , lymphoma , biology , lymphoblast , cancer research , cell , sister chromatids , pathology , microbiology and biotechnology , immunology , medicine , genetics , in vitro , chromosome , gene
The sister chromatid exchange (SCE) rates of cell lines derived from patients with different malignant and premalignant diseases were studied before and after intracerebral inoculation into nude mice and were compared to the SCE frequencies of cell lines from healthy controls. Lymphoma lines characterized by chromosomal markers as well as chromosomally normal lymphoblastoid cell lines were used. The SCE frequencies of nude mouse tumor‐derived cell lines did not show a homogeneous pattern. They were either as high as, or higher or lower than, the SCE levels of the original cell line. But all cell lines, karyotypically abnormal as well as normal, originating from patients with malignant and premalignant diseases, showed significantly higher SCE rates than the control lines from healthy donors.