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EBV‐positive Burkitt's lymphoma from algeria, with a three‐way rearrangement involving chromosomes 2, 8 and 9
Author(s) -
Philip T.,
Lenoir G. M.,
Fraisse J.,
Philip I.,
Bertoglio J.,
Ladjaj S.,
Bertrand S.,
BrunatMentigny M.
Publication year - 1981
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910280404
Subject(s) - chromosomal translocation , lymphoma , burkitt's lymphoma , virus , chromosome , biology , karyotype , cytogenetics , chromosomal rearrangement , virology , pathology , medicine , immunology , genetics , gene
Burkitt's lymphoma was diagnosed in a male Algerian child presenting with abdominal and jaw tumours. Viral studies revealed that this non‐endemic case was associated with the Epstein‐Barr virus. Cytogenetic examination of tumour cells showed a complex three‐way rearrangement involving chromosomes 2, 8 and 9. Our report indicates that, in Burkitt's lymphoma, not only simple but also complex translocations involving chromosome 8 may arise. This finding in a North African case emphasizes the need for more detailed study of the clinical, virological and cytogenetic features of Burkitt's lymphoma throughout the world.