Premium
Effect of bacillus calmette‐guéarin cell wall skeleton on the induction of the cytotoxic and suppressor T cells against syngeneic tumor in the mouse
Author(s) -
Koyama Shohei,
Fujimoto Shigeyoshi,
Tada Tomio,
Sakita Takao
Publication year - 1981
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910270615
Subject(s) - cytotoxic t cell , suppressor , biology , cancer research , in vitro , immunology , microbiology and biotechnology , cancer , biochemistry , genetics
The effect of Bacillus Calmette‐Guérin cell wall skeleton (BCG‐CWS), which is one of the well‐established immunopotentiators, on the induction of either cytotoxic or suppressor T cells against syngeneic tumor S1509a was investigated by an in vitro assay system. BCG‐CWS showed an apparent augmenting activity in the induction of cytotoxic T cells against a syngeneic tumor when it was administered subcutaneously into mice with mitomycin C (MMC)‐treated tumor cells in a form of oil‐in‐water emulsion. In addition, cytotoxic T cell activity was dominantly generated in regional lymph nodes. Furthermore, the immunized animals developed stronger resistance against the second inoculum of the same viable tumor cells. However, BCG‐CWS had no effect on the induction of suppressor T cells in tumor‐bearing host (TBH), and could not induce cytotoxic T cells against the homologous tumor in TBH in which suppressor T cells had been readily activated. The growth of tumor was neither suppressed nor enhanced, even if an oil‐attached BCG‐CWS was administered in TBH.