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Control of a human tumour (ewing sarcoma) in mice by a single lethal dose of dimethyl‐myleran and bone marrow
Author(s) -
Floersheim G. L.,
Torhorst J.
Publication year - 1981
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910270603
Subject(s) - sarcoma , bone marrow , medicine , osteosarcoma , ewing's sarcoma , pathology , ratón , immunology
A Ewing sarcoma grown in immunosuppressed mice was eradicated with a single lethal dose of dimethylmy‐leran (DMM) followed by autologous or syngeneic bone marrow. Sarcomas treated 2 weeks after grafting in a phase of rapid proliferation disappeared and large sarcomas treated after 6 or 10 weeks were reduced to necrotic tissue. A human osteosarcoma also regressed distinctly after this therapy while a human colon carcinoma responded poorly. Sub‐lethal DMM treatment induced complete remissions in only 62% of the mice. Tumours which display sensitivity in this model may be treated clinically with lethal doses of DMM and autologous marrow transplantions.