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Metastasis and the reticuloendothelial system. II. Effect of triamcinolone acetonide on organ retention of malignant cells in endotoxin‐treated mice
Author(s) -
Glaves Dorothy,
Weiss Leonard
Publication year - 1981
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910270409
Subject(s) - triamcinolone acetonide , mononuclear phagocyte system , melanoma , medicine , lung , baboon , pathology , immunology , pharmacology , cancer research
The lung retention patterns of B16 melanoma cells were determined after intravenous injection of [ 125 I]dUrd‐labelled tumor cells into B16 melanoma‐bearing mice. Experiments were performed to assess the effects of a synthetic glucocorticoid, triamcinolone acetonide, on the retention of B16 melanoma cells arrested in the lungs of mice with endotoxin‐induced reticuloendothelial system hyperfunction. Lung clearance of malignant cells was greatly accelerated in mice treated with endotoxin alone but was markedly inhibited in mice with only triamcinolone acetonide. In mice treated with both endotoxin and subsequently triamcinolone acetonide after tumor‐cell arrest processes had occurred, the endotoxin‐induced increase in clearance was nullified. These results are discussed in terms of the mutually antagonistic activity of both pharmacologic agents upon the reticuloendothelial system and the role of the latter in regulating organ retention of disseminated malignant cells.