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Experimental studies of tumor radioimmunodetection using antibody mixtures against carcinoembryonic antigen (CEA) and colon‐specific antigen‐p (CSAp)
Author(s) -
Gaffar Shaik A.,
Pant Keshab D.,
Shochat Dan,
Bennett Sidney J.,
Goldenberg David M.
Publication year - 1981
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910270116
Subject(s) - carcinoembryonic antigen , antigen , antibody , colonic carcinoma , colorectal cancer , medicine , colonic cancer , pathology , cancer , carcinoma , immunology
Experiments with the GW‐39 human colonic carcinoma growing in hamsters showed that injection of radioactive antibody to a colorectal‐specific, tumor‐associated antigen, CSAp, results in better tumor radiolocalization than was seen previously with radioantibodies to carcinoembryonic antigen (CEA). However, a mixture of both radioactive antibodies resulted in potentiation of CEA‐tumor radioimmunodetection without affecting CSAp‐tumor radiolocalization. Hence, multi‐marker antibody mixtures may be the method of choice in cancer radioimmunodetection.

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