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Chromosome 15 trisomy in spontaneous and carcinogen‐induced murine lymphomas of B‐cell origin
Author(s) -
Wiener F.,
Babonits M.,
Spira J.,
Bregula U.,
Klein G.,
Merwin R. M.,
Asofsky R.,
Lynes M.,
Haughton G.
Publication year - 1981
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910270109
Subject(s) - trisomy , chromosomal translocation , biology , aneuploidy , chromosome , genetics , carcinogen , cancer research , chromosome 21 , microbiology and biotechnology , gene
G‐banding analyses of 14 independently derived B‐cell lymphomas showed the frequent occurrence of chromosome 15 trisomy. It was present in seven of nine spontaneous B‐cell lymphomas, but in company with other trisomies, monosomies and marker chromosomes. In five carcinogen‐induced primary B‐cell leukemias, trisomy 15 was the dominating change. Taken together with the previously demonstrated importance of chromosome 15 trisomy for T‐cell leukemogenesis and of the 12;15 translocation in plasmacytogenesis in the mouse, it appears likely that the distal part of chromosome 15 carries a cluster of genes, perhaps a supergene region, that may play an important role in the differentiation and/or the normal responsiveness of various lymphoreticular cell types to growth control.