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Chromosome pattern, growth in agar and tumorigenicity in nude mice of four human bladder carcinoma cell lines
Author(s) -
Hastings R. J.,
Franks L. M.
Publication year - 1981
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910270104
Subject(s) - carcinoma , cell culture , biology , nude mouse , chromosome , agar , pathology , cancer research , medicine , genetics , bacteria , gene
Four human bladder carcinoma cell lines have been characterized by G‐banding, and the chromosomal patterns correlated to growth in agar and tumorigenicity in nude mice. Each cell line was shown to be chromosomally unique and although numerical and structural anomalies were present, none were common to all four cell lines. However, one or more copies of a structurally altered chromosome 8 were present in all four cell lines and may be associated with tumorigenicity in nude mice. A combination of three marker chromosomes was found in the more anaplastic cell lines, but not in the two well‐differentiated tumour cell lines. Growth in agar may be associated with the presence of the three marker chromosomes but was not correlated with tumorigenicity in nude mice.