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Adhesion of metastatic and non‐metastatic carcinoma cells to glass surfaces
Author(s) -
CottlerFox M.,
Ryd W.,
Hagmar B.,
Fox C. H.
Publication year - 1980
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910260523
Subject(s) - renal cell carcinoma , metastasis , adhesion , pathology , carcinoma , in vitro , cell adhesion , cancer research , medicine , biology , chemistry , cancer , biochemistry , organic chemistry
Adhesion in vitro is described in cells from a tumor pair originating from a single methylcholanthrene‐induced mouse carcinoma. One member of this tumor pair shows a high incidence of metastases while the other does not metastasize. Cells from the non‐metastasizing carcinoma were found to form close and focal contacts with a glass substrate consecutively, as do normal mouse kidney epithelial cells. Cells from the metastasizing carcinoma, however, had only limited areas of close contact and generally failed to form focal contacts. It is suggested that this alteration in cell‐substrate adhesion contributes to the release and mobility of metastatic cells.