General report on the second international workshop on chromosomes in leukemia | Zendy

Rowley J. D. | Zendy

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General report on the second international workshop on chromosomes in leukemia

Author(s) -

Rowley J. D.

Publication year - 1980

Publication title -

international journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.475

H-Index - 234

eISSN - 1097-0215

pISSN - 0020-7136

DOI - 10.1002/ijc.2910260502

Subject(s) - preleukemia , karyotype , chromosomal translocation , leukemia , cytogenetics , oncology , biology , medicine , chromosome , genetics , gene

The Workshop participants were able to establish that the t(8;21) and t(15;17) are each definitely associated with a particular type of ANLL, namely, AML‐M2 and APL‐M3 and M3 variant, respectively. Both translocations, particularly the t(15;17), have an uneven geographical distribution which cannot presently be explained. The data also show that patients with preleukemia and an abnormal karyotype have a very poor prognosis with a fatal outcome in 60%, compared with only 30% for patients with a normal karyotype.

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