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Herpesvirus saimiri: Protective effect of attenuated strain against lymphoma induction
Author(s) -
Wright John,
Falk Lawrence A.,
Wolfe Lauren G.,
Deinhardt Friedrich
Publication year - 1980
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910260413
Subject(s) - strain (injury) , virology , lymphoma , medicine , biology , immunology
An attenuated strain of Herpesvirus saimiri (A‐HVS) induced a persistent, latent infection in common marmosets. Virus was recovered from circulating lymphocytes of infected animals and antibody response to virus‐specified antigens was demonstrated over 3‐12 months PI. A‐HVS‐infected common marmosets and animals without previous A‐HVS exposure were challenged with oncogenic HVS (125‐825 PFU); marmosets without A‐HVS infection developed malignant lymphoproliferative disease and died 3 weeks PI whereas all persistently‐infected animals have survived 38‐43 months post challenge.