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Regulation of natural killer activity in vivo . II. The effect of alcohol consumption on human peripheral blood natural killer activity
Author(s) -
Saxena Queen B.,
Mezey Esteban,
Adler William H.
Publication year - 1980
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910260405
Subject(s) - k562 cells , natural killer cell , peripheral blood , lymphokine activated killer cell , immunology , biology , in vivo , peripheral , chemistry , in vitro , cytotoxicity , immune system , medicine , biochemistry , interleukin 21 , t cell , leukemia , microbiology and biotechnology
Natural killer (NK) activity of human peripheral blood lymphocytes (HPBL) was studied in 32 alcoholics and 15 control subjects in a 4‐h chromium release assay using K562 tumor target cells. The natural killer activity of human peripheral blood lymphocytes in alcoholics was significantly higher than the level found in the control group. NK activity of PBL from alcoholics was still higher than that of similarly treated PBL from control subjects after carbonyl iron and magnet treatment, or after passage through a nylon wool column or after removal of cells rosetting with sheep erythrocytes. Changes in T cell, B cell or macrophage populations, therefore, are not the mechanism for increased NK activity in alcoholics.