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NATURAL CELLULAR REACTIVITIES MEDIATED BY SPLENOCYTES FROM MICE BEARING THREE TYPES OF PRIMARY TUMOR
Author(s) -
Ehrlich Rachel,
Efrati Margalit,
BarEyal Aviva,
Wollberg Miriam,
Schiby Ginette,
Ran Maya,
Wrrz Issac P.
Publication year - 1980
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910260310
Subject(s) - splenocyte , dmba , cytostasis , cancer research , biology , immunology , spleen , medicine , carcinogenesis , in vitro , cytotoxicity , cancer , biochemistry
The ability of splenocytes from mice bearing three types of primary tumor to lyse YAC‐l target cells (NK activity) and to inhibit [ 125 l]dUrd incorporation ([ 125 l]dUrd l‐l = cytostasis) into B16‐F10 target cells was compared to the ability of normal splenocytes to perform such activities. The tumor systems used were urethane‐induced lung adenomas in BALB/c mice, di‐methylbenzanthracene (DMBA)‐induced tumors in hormonally‐stimulated BALB/c mice and mammary tumors in force‐bred C3HeB mice. The two types of natural cellular reactivity in lung adenoma‐bearing mice were unaffected. The NK activity of mice bearing DMBA and forced‐breeding‐induced tumors was suppressed. The cytostatic ability of splenocytes from mice bearing DMBA‐induced tumors was significantly elevated. The spleens of mice bearing primary DMBA‐induced tumors contained cells able to suppress NK activity or to compete against target cells for NK cells.