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Organization of actin‐containing cables in cultured skin fibroblasts from individuals at high risk of colon cancer
Author(s) -
Kopelovich Levy,
Lipkin Martin,
Blattner William A.,
Fraumeni Joseph F.,
Lynch Henry T.,
Pollack Robert E.
Publication year - 1980
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910260308
Subject(s) - colorectal cancer , asymptomatic , rectum , carcinogenesis , offspring , cancer , actin , pathology , medicine , fibroblast , biology , phenotype , cancer research , gene , genetics , in vitro , pregnancy
Abstract Actin‐containing cables were examined by immuno‐fluorescence in cultured skin fibroblasts from individuals genetically prone to colon cancer. The study confirmed our earlier finding of an altered distribution of actincontaining cables in skin fibroblasts of patients with hereditary adenomatosis of the colon and rectum (ACR) (Kopelovich et al. , 1977). Abnormalities were also found in about one‐half of the asymptomatic offspring at risk for ACR, while a polyposis‐free branch of one ACR family showed a normal pattern of actin‐containing cables. Persons from colon cancer‐prone (CCP) families without polyposis, and normal controls, showed no disturbance in the actin patterns. The results suggest that this phenotypic marker may be useful in identifying ACR gene carriers and in probing cellular controls of carcinogenesis.