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Induction of immune reaction against rat embryonal carcinoma by activation of viral genome
Author(s) -
Sobis H.,
Van Hove L.,
Heremans H.,
De Ley M.,
Billiau A.,
Vandeputte M.
Publication year - 1980
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910260115
Subject(s) - biology , genome , virus , superinfection , virology , embryonal carcinoma , immune system , cell culture , helper virus , endogeny , gene , viral replication , immunology , cellular differentiation , genetics , endocrinology
A cell line (F3/I) derived from a rat embryonal carcinoma, originally induced in fetectomized rats injected with MSV, was found to be essentially non‐immunogenic in a syngeneic host; the cells did not produce C‐type virions. The MSV genome could be rescued by superinfection of F3/I cells with endogenous C‐type mouse virus and the cells were converted in a producer line‐F3/l‐P. The produced virus was shown to be MSV by its ability to induce focus formation in mouse fibroblasts. In contrast to its non‐producer ancestor, the F3/ I‐P line proved to be strongly immunogenic in the syngeneic host. These results indicate the possibility of converting certain non‐immunogenic tumors into immunogenic ones by the activation of dormant viral genome using xenogeneic non‐oncogenic helper virus.