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Lymphocytes that mediate systemic resistance to in vivo growth of a carcinogen‐induced syngeneic tumor
Author(s) -
Crum E. D.
Publication year - 1980
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910260109
Subject(s) - methylcholanthrene , sarcoma , in vivo , thoracic duct , lymph , carcinogen , cancer research , pathology , neoplasm , medicine , life span , immunology , biology , genetics , microbiology and biotechnology , gerontology
Abstract Wistar rats immunized with irradiated syngeneic methylcholanthrene‐induced sarcoma, Mc7, are able to suppress a subsequent challenge of this tumor. Cells obtained from thoracic‐duct lymph of these tumor‐immunized animals and infused intravenously into normal syngeneic rats transfer specific tumor resistance to the recipients. These mediators of tumor resistance have the characteristics of T lymphocytes that are in a non‐proliferating state and have an effective life span of at least 2 weeks in normal recipient rats.