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Cytogenetic studies on abelson‐virus‐induced mouse leukemias
Author(s) -
Klein George,
Ohno Shinsuke,
Rosenberg Naomi,
Wiener Francis,
Spira Jack,
Baltimore David
Publication year - 1980
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910250617
Subject(s) - biology , karyotype , gene duplication , trisomy , virus , ploidy , virology , chromosomal translocation , chromosome , microbiology and biotechnology , genetics , gene
The karyotype of Abelson‐virus‐induced murine leukemias was studied by G‐banding. In contrast to the regular trisomy of chromosome 15 in most murine T‐cell leukemias, Abelson leukemias were purely diploid, and remained diploid for up to seven consecutive passages in vivo. The hypothesis is advanced that integration into the recipient cell of the DNA copy of the large cellular insert, carried by the Abelson virus, may perform a function similar to the effects of gene duplication by trisomy in the more slowly developing murine leukemias.