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Somatic cell hybrids producing antibodies specific to human fibronectin
Author(s) -
Zardi Luciano,
Carnemolla Barbara,
Siri Annalisa,
Santi Leonardo,
Accolla Roberto S.
Publication year - 1980
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910250304
Subject(s) - fibronectin , somatic cell , hypoxanthine guanine phosphoribosyltransferase , antibody , monoclonal antibody , biology , microbiology and biotechnology , hypoxanthine phosphoribosyltransferase , spleen , cell , immunology , biochemistry , gene , mutant
We have produced somatic cell hybrids between mouse plasmocytoma cells deficient in hypoxanthine phosphoribosyltransferase (P3 × 63 Ag8) and spleen cells derived from mice immunized with purified human plasma fibronectin. We report herein the properties of monoclonal anti‐fibronectin antibodies released by eight different clones.