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Cytotoxic effector cells with the characteristics of natural killer cells in the lungs of mice
Author(s) -
Puccetti Paolo,
Santoni Angela,
Riccardi Carlo,
Herberman Ronald B.
Publication year - 1980
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910250121
Subject(s) - cytotoxic t cell , effector , immunology , lymphokine activated killer cell , natural killer t cell , biology , cytotoxicity , natural killer cell , microbiology and biotechnology , interleukin 12 , in vitro , biochemistry
Cells with in vitro cytotoxicity against tumor targets in a short‐term 51 Cr release assay have been recovered from the lungs of mice that were either untreated or injected with biological or synthetic agents 1–3 days earlier. The cytotoxic effector cells were non‐adherent, non‐phagocytic and shared many characteristics with splenic natural killer (NK) cells. This finding is discussed with particular regard to our previous observations on the rapid in vivo elimination from the lungs of intravenously injected, radiolabelled tumor cells.