Activated T lymphocytes in infiltrates and draining lymph nodes of nasopharyngeal carcinoma | Zendy

Galili Uri | Zendy; Klein Eva | Zendy; Klein George | Zendy; Bal Inderjit Singh | Zendy

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Activated T lymphocytes in infiltrates and draining lymph nodes of nasopharyngeal carcinoma

Author(s) -

Galili Uri,

Klein Eva,

Klein George,

Bal Inderjit Singh

Publication year - 1980

Publication title -

international journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.475

H-Index - 234

eISSN - 1097-0215

pISSN - 0020-7136

DOI - 10.1002/ijc.2910250111

Subject(s) - nasopharyngeal carcinoma , lymph , pathology , medicine , carcinoma , epithelioma , radiation therapy

Lymphocytes isolated from the tumors and draining lymph nodes of nasopharyngeal carcinoma (NPC) patients exhibit the following characteristics of immune activation: (1) stable E rosette formation, (2) natural attachment to various human cells, (3) sensitivity in vitro to the lytic effect of glucocorticoids. Although the NPC T cells attach in vitroto various cells they kill only EBV‐genome‐carrying targets. These findings suggest the occurrence of a local cellular immune response in NPC, possibly directed to EBV‐determined antigens.

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