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Activated T lymphocytes in infiltrates and draining lymph nodes of nasopharyngeal carcinoma
Author(s) -
Galili Uri,
Klein Eva,
Klein George,
Bal Inderjit Singh
Publication year - 1980
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910250111
Subject(s) - nasopharyngeal carcinoma , lymph , pathology , medicine , carcinoma , epithelioma , radiation therapy
Lymphocytes isolated from the tumors and draining lymph nodes of nasopharyngeal carcinoma (NPC) patients exhibit the following characteristics of immune activation: (1) stable E rosette formation, (2) natural attachment to various human cells, (3) sensitivity in vitro to the lytic effect of glucocorticoids. Although the NPC T cells attach in vitroto various cells they kill only EBV‐genome‐carrying targets. These findings suggest the occurrence of a local cellular immune response in NPC, possibly directed to EBV‐determined antigens.