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Immunological basis for differences in susceptibility to hydrocarbon oncogenesis among mice of a single genotype
Author(s) -
Prehn Richmond T.
Publication year - 1979
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910240616
Subject(s) - genotype , inbred strain , carcinogenesis , immune system , biology , thymectomy , strain (injury) , mouse strain , immunology , genetics , gene , anatomy , myasthenia gravis
The tendency for tumor induction to occur preferentially in certain individual mice of an inbred strain vanished when the putative immune response was reduced either by radiation plus thymectomy or by reduction of the concentration of the chemical oncogen.