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Lung carcinoma induction in BD rats after a single intratracheal instillation of an arsenic‐containing pesticide mixture formerly used in vineyards
Author(s) -
Ivankovic S.,
Eisenbrand G.,
Preussmann R.
Publication year - 1979
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910240615
Subject(s) - pesticide , intratracheal instillation , arsenic , carcinogen , lung , carcinoma , arsenate , pathology , chemistry , biology , medicine , bronchoalveolar lavage , agronomy , biochemistry , organic chemistry
A single intratracheal 0.1‐ml instillation of a calcium‐arsenate containing vineyard pesticide induced multi‐focal bronchogenic adenocarcinomas and bronchiolar‐alveolar‐cell carcinomas in nine out of 15 treated BD rats. This seems to be the first experimental confirmation of carcinogenicity of arsenic‐containing pesticides used formerly in vineyards.